During perimenopause, the decrease in estrogen levels can have a significant impact on both insulin sensitivity and appetite.

Insulin Sensitivity During Perimenopause

Insulin Sensitivity

Menopause symptoms can significantly impact a woman’s quality of life, affecting your physical, emotional, and social well-being. Personalized care aims to address the unique challenges and concerns of each woman, helping to minimize the impact of symptoms on your daily life. By tailoring interventions and treatment plans, healthcare providers can work with us to improve our overall well-being and enhance your quality of life during this transitional phase. Estrogen plays a role in maintaining insulin sensitivity, which is the ability of cells to respond to the hormone insulin and properly regulate blood sugar levels. When estrogen levels decline, insulin sensitivity can be reduced. This means that the body may become less efficient at using insulin to transport glucose from the bloodstream into the cells for energy. As a result, blood sugar levels may rise, leading to a condition known as insulin resistance.

Insulin resistance can have several effects on appetite and metabolism. Insulin resistance can lead to higher levels of insulin in the blood, as the body produces more insulin to compensate for the reduced sensitivity. Elevated insulin levels can stimulate appetite and promote the storage of excess calories as fat, contributing to weight gain.

Insulin resistance can disrupt the balance of other appetite-regulating hormones. For example, it can increase the production of ghrelin, a hormone that stimulates hunger, while reducing the production of leptin, a hormone that signals satiety. This can result in increased feelings of hunger and reduced feelings of fullness, making it more challenging to control appetite and maintain a healthy weight.


Personalized care allows healthcare providers to offer targeted treatment options based on a woman’s specific symptoms and medical history. This may include hormone therapy, lifestyle modifications, alternative therapies, or a combination of approaches. By tailoring the treatment plan, women are more likely to receive interventions that directly address your symptoms, leading to better outcomes and symptom management. The decrease in estrogen levels during perimenopause can also directly affect appetite. Estrogen influences the production and sensitivity of various appetite hormones, including ghrelin and leptin. When estrogen levels decline, the production and effectiveness of these hormones can be disrupted.

Ghrelin, known as the “hunger hormone,” stimulates appetite and promotes food intake. When estrogen levels decrease, ghrelin production may increase, leading to heightened feelings of hunger and cravings for food.

Leptin, on the other hand, is a hormone produced by fat cells that signals to the brain when the body has had enough food. Estrogen helps regulate the production and sensitivity of leptin. When estrogen levels decline, the production and effectiveness of leptin can be affected. This can lead to a decrease in leptin signaling, causing the brain to perceive a state of hunger and reducing feelings of fullness.

Managing Insulin Sensitivity and Appetite

These hormonal changes can contribute to changes in appetite, increased hunger, cravings, and difficulty in managing weight during perimenopause. It is important to adopt a healthy lifestyle, including a balanced diet and regular exercise, to support appetite regulation and manage insulin sensitivity. Working with a healthcare provider can also help determine the most appropriate treatment options, such as hormone replacement therapy or other interventions, to address these hormonal changes and their effects on appetite and metabolism.

Explore Better Hormone Health

ReVital offers free consultations where you can speak to one of our clinicians about ReVital’s Bioidentical Hormone Replacement Therapy. At ReVital, we can conduct simple blood tests to evaluate the levels of these hormones in your system and prescribe supplements or therapies to treat and control the majority of hormonal imbalances. Remember, every woman’s experience is unique, so it’s important to consult with your primary healthcare professional for guidance and support throughout your personal health journey.